Table 1

Associations between calpastatin, calpain-1 and calpain-2 protein expression and various clinicopathological variables in the pancreatic cancer cohort
Calpain-1 Calpain-2 Calpastatin (cytoplasmic) Calpastatin (nuclear)
Low High p value Low High p value Low High p value Low High p value
Age
 ≤ 60 years (n=23) 17 (34.7) 4 (30.8) 1.000* 3 (18.8) 18 (37.5) 0.225* 16 (32.0) 4 (33.3) 1.000* 15 (33.3) 5 (29.4) 1.000*
 > 60 years (n=45) 32 (65.3) 9 (69.2) 13 (81.3) 30 (62.5) 34 (68.0) 8 (66.7) 30 (66.7) 12 (70.6)
Tumour size
 ≤ 2cm (n=17) 16 (33.3) 1 (7.7) 0.088* 5 (31.3) 12 (25.5) 0.747* 13 (26.5) 3 (25.0) 1.000* 10 (22.7) 6 (35.3) 0.317
 > 2cm (n=50) 32 (66.7) 12 (92.3) 11 (68.8) 35 (74.5) 36 (73.5) 9 (75.0) 34 (77.3) 11 (64.7)
T stage
 2 (n=12) 6 (12.2) 3 (23.1) 0.335 2 (12.5) 9 (18.8) 0.576 8 (16.0) 3 (25.0) 0.380 8 (17.8) 3 (17.6) 0.766
 3 (n=54) 42 (85.7) 9 (69.2) 14 (87.5) 37 (77.1) 41 (82.0) 8 (66.7) 36 (80.0) 13 (76.5)
 4 (n=2) 1 (2.0) 1 (7.7) 0 (0.0) 2 (4.2) 1 (2.0) 1 (8.3) 1 (2.2) 1 (5.9)
N stage
 Negative (n=22) 17 (35.4) 4 (33.3) 1.000* 3 (18.8) 18 (39.1) 0.220* 15 (30.6) 5 (45.5) 0.481* 14 (31.8) 6 (37.5) 0.760*
 Positive (n=44) 31 (64.6) 8 (66.7) 13 (81.3) 28 (60.9) 34 (69.4) 6 (54.5) 30 (68.2) 10 (62.5)
Vascular invasion
 absent (n=24) 19 (38.8) 4 (30.8) 0.751* 3 (18.8) 20 (41.7) 0.136* 19 (38.0) 4 (33.3) 1.000* 15 (33.3) 8 (47.1) 0.318
 present (n=44) 30 (61.2) 9 (69.2) 13 (81.3) 28 (58.3) 31 (62.0) 8 (66.7) 30 (66.7) 9 (52.9)
Perineural invasion
 absent (n=14) 8 (16.3) 5 (38.5) 0.122* 1 (6.3) 12 (25.0) 0.157* 11 (22.0) 2 (16.7) 1.000* 10 (22.2) 3 (17.6) 1.000*
 present (n=54) 41 (83.7) 8 (61.58) 15 (93.8) 36 (75.0) 39 (78.0) 10 (83.3) 35 (77.8) 14 (82.4)

The frequency of observed clinicopathological variables is noted next to the variable subgroup; one case did not have available data for tumour size. The P values are resultant from Pearson Chi Square test of association (χ2) or Fisher’s Exact test in a 2×2 table if a cell count was less than 5 (indicated by *). Significant P values are indicated by bold font.

Storr et al.

Storr et al. BMC Cancer 2012 12:511   doi:10.1186/1471-2407-12-511

Open Data