Single patient personalized monitoring of ST and global sbsRT proportions during disease progression. ST and global sbsRT proportions were calculated for 4 L-SAGE experiments carried out on the biopsies of a single patient at 1 healthy and 3 consecutive tumor stages. Gray bars = ST proportions, black bars = global sbsRT proportions. Low-grade dysplasia (LGD), High-grade dysplasia (HGD) and adenocarcinoma (cancer). The global sbsRT proportions were calculated using 1.435 RT present in all 4 experiments. Significance of ST proportion differences between healthy, LGD, HGD and adenocarcinoma was calculated using the Pearson’s chi-squared proportion test (p-value < 2.2 x 10-16).
Bianchetti et al. BMC Cancer 2012 12:509 doi:10.1186/1471-2407-12-509