Diversity of sbsRT in healthy and cancer cells. SBS were tracked for 8,572 RT in 7 healthy (circles) and 8 cancer (triangles) Tag-seq experiments. The 8,572 RT were distributed into sequence diversity groups according to the number of distinct sbsRT sequences. For example, group 0, i.e. RT for which 0 sbsRT were observed, contained approximately 350 RT in cancer and slightly more than 800 RT in healthy cells. RT associated with more than 30 distinct sbsRT were rare.
Bianchetti et al. BMC Cancer 2012 12:509 doi:10.1186/1471-2407-12-509