Table 3

Correlation of biomarkers with therapy response

Responder

Non-Responder

Marker

Time [hours]

Median

Range

Median

Range

p-Value


Nucleosomes

[ng/mL]

0

198.5

17.4-1624

174.7

5.0-1617

0.991

24

239.1

55.6-1225

844.8

21.7-4334

0.003

48

677.2

51.7-2095

594.9

133.3-2547

0.851


CYFRA 21-1

[ng/mL]

0

6.9

0.8-32.8

14.0

1.3-246.0

0.031

24

28.4

1.0-118.0

30.8

2.9-811.0

0.493

48

19.6

1.5-404.0

28.5

2.6-638.0

0.293


CEA

[ng/mL]

0

162.0

4.0-986.0

557.0

2.0-31620

0.037

24

265.5

2.6-5011

540.5

1.6-36120

0.087

48

229.5

2.2-4073

524.0

1.6-37550

0.063


CA 19-9

[U/L]

0

18.6

2.4-159.0

148.0

2.4-11530

0.001

24

17.9

2.5-298.0

158.0

2.4-18550

0.004

48

20.9

2.4-260.0

187.5

2.3-17000

0.002


LDH

[U/L]

0

349.0

178.0-544.0

529.5

220.0-3068

0.011

24

450.0

143.0-1117

532.0

148.0-2923

0.522

48

572.0

142.0-1488

607.5

168.0-3585

0.434


CRP

[mg/dL]

0

0.9

0.3-5.1

2.4

0.1-20.3

0.227

24

1.1

0.1-2.8

2.8

0.2-21.8

0.159

48

4.4

0.1-16.3

4.6

0.3-15.1

0.507


AST

[U/L]

0

37.5

24.0-94.0

56.0

24.0-190.0

0.037

24

111.0

32.0-169.0

69.0

15.0-339.0

0.782

48

85.0

33. 0-179.0

66.0

19.0-317.0

0.912


ALT

[U/L]

0

38.0

15.0-63.0

30.0

15.0-268.0

0.658

24

52.0

26.0-131.0

37.0

14.0-178.0

0.108

48

54.0

23.0-112.0

34.0

13.0-136.0

0.113


GGT

[U/L]

0

183.5

44. 0-432.0

189.0

33.0-712.0

0.782

24

168.5

46.0-391.0

164.0

31.0-577.0

0.965

48

177.5

60.0-406.0

170.0

31.0-653.0

0.903


AP

[U/L]

0

153.0

89.0-569.0

193.0

81.0-742.0

0.559

24

156.0

78.0-588.0

151.0

63.0-655.0

0.707

48

156.0

77.0-504.0

164.0

61. 0-630.0

0.674


Bilirubin

[mg/dL]

0

0.7

0.3-1.4

0.8

0.3-1.9

0.438

24

0.9

0.4-1.7

1.0

0.4-2.2

0.920

48

1.1

0.5-2.4

1.2

0.4-2.8

0.799


CHE

[kU/L]

0

8.3

4.9-11.1

6.5

2.8-10.8

0.017

24

7.1

5.1-11.1

5.7

2.8-10.4

0.009

48

6.9

4.5-10.5

5.3

2.3-9.7

0.006


Amylase

[U/L]

0

64.5

20.0-105.0

54.0

24.0-136.0

0.346

24

45.5

21.0-79.0

44.0

20.0-429.0

0.833

48

50.5

20.0-58.0

46.0

23.0-519.0

0.842


Lipase

[U/L]

0

27.0

3.0-149.0

25.0

3.0-263.0

0.725

24

17.5

4.0-33.0

18.0

3.0-585.0

0.773

48

16.5

3.0-42.0

22.0

3.0-495.0

0.330


P-values (by Wilcoxon-test) are shown for the various response groups.

There was a significant correlation between therapy response and survival time in this setting (s = 0.034). (Figure 2A).

Fahmueller et al. BMC Cancer 2012 12:5   doi:10.1186/1471-2407-12-5

Open Data