Table 5

Testing for significance of variation in β by various factors considered one at a time
Factor Level Blocks includeda Nb β (95% CI) Deviancec
None All 1-32 32 0.018 (0.016-0.021) 44.01
Sex Male 1,3-6,12-16,19,21,23-27,31 18 0.019 (0.016-0.022) 42.33
Female 17,20,22,28-30 6 0.015 (0.008-0.022)
Both 2,7-11,18,32 8 0.018 (0.012-0.024)
Publication year <1990 1,14,18-20,24 6 0.025 (0.012-0.038) 40.12
1990-1994 5,7-9,13,25-31 12 0.016 (0.012-0.020)
1995+ 2-4,6,10-12,15-17,21-23,32 14 0.019 (0.016-0.023)
Mean age <50 5,6,11,12,14,15,19-21,31 10 0.024 (0.020-0.028) 29.12**
50-59 1,3,4,9,13,16-18,25-30 14 0.015 (0.012-0.018)
60+ 2,7,8,10,22-24,32 8 0.017 (0.011-0.022)
Quality score 8 or 9

3,4,7-9,11-13,16,17,19,20,22,23,

25–30,32

21 0.017 (0.014-0.020) 40.20
5 to 7 1,2,5,6,10,14,15,18,21,24,31 11 0.022 (0.017-0.026)
Continent North America 1,3,4,6-8,10-13,18-20,22-30,32 23 0.018 (0.014-0.021) 43.46
Other 2,5,9,14-17,21,31 9 0.019 (0.016-0.023)
Disease fatality Deaths 1,5,9,12,14,15,19-21,24,31 11 0.024 (0.020-0.027) 28.99**
Incidence 13,22,23,25-30 9 0.015 (0.011-0.020)
Both 2-4,6-8,10,11,16-18,32 12 0.015 (0.012-0.019)
Population type General 1,7-9,11,14,16,17,19-21,25-30 17 0.016 (0.013-0.019) 37.74*
Other 2-6,10,12,13,15,18,22-24,31,32 15 0.021 (0.018-0.025)
Exposed to lung carcinogens Yes 3-6 4 0.016 (0.006-0.025) 43.44
No 1,2,7-32 28 0.019 (0.016-0.021)
Follow-up period 1-15 2,9,10,18-20,24,32 8 0.020 (0.013-0.027) 41.72
16-23 3-6,11,13,16,17,22,23,31 11 0.016 (0.012-0.021)
24+ 1,7,8,12,14,15,21,25-30 13 0.019 (0.016-0.023)
Adjusted for smoking Yesd 2-4,7-13,15-17,19,20,22-30,32 25 0.018 (0.016-0.021) 43.98
No 1,5,6,14,18,21,31 7 0.019 (0.009-0.029)
Measure of FEV1 reported FEV1%P 1-4,6-11,13,15-18,21-24,32 20 0.018 (0.015-0.021) 43.93
Other 5,12,14,19,20,25-31 12 0.019 (0.014-0.024)
Weight of β <125 1,5-7,18-20,24,25,28,29 11 0.021 (0.010-0.031) 43.54
125-250 2,3,8,10,14,21-23,26,31,32 11 0.017 (0.012-0.023)
250+ 4,9,11-13,15-17,27,30 10 0.019 (0.015-0.022)
Original data recorded as Regression coefficient 7,8,10,22,23 5 0.017 (0.008-0.026) 43.02
RR (CI) 1-4,9,11-13,15-18,21,24-30,32 21 0.018 (0.016-0.021)
SMR/SIR 5,6,14,19,20,31 6 0.022 (0.011-0.034)

a See Tables 3 and 4 for definition of blocks.

b Number of estimates of β which are combined.

c The significance of the factor is assessed by comparing the deviance for the model including that factor and the deviance for the null (no factor) model and is indicated by *p<0.05 **p<0.01 *** p<0.001.

d This includes blocks which relate to the whole population, current smokers or ever smokers which adjust at least for a measure of dose, such as cigs/day or pack yrs, and blocks which are restricted to nonsmokers.

Fry et al.

Fry et al. BMC Cancer 2012 12:498   doi:10.1186/1471-2407-12-498

Open Data