Table 3

Dose escalation schemes and dose-limiting toxicities on cycle one
PR104 Dose Patients Dose-limiting toxicities
Level mg/m2 (n)
Group A PR104 + gemcitabine 1 275 3 Grade 4 thrombocytopenia (n=2)
2 140 6 -
Group B PR104 + docetaxel 60 1 400 3 Grade 3 neutropenic fever (n=1)
2 200 3 Grade 3 neutropenic fever (n=2)
Group C PR104 + docetaxel 60 + GCSF 1 200 3 -
2 400 3 -
3 550 3 -
4 770 6 -
5 1100 6 Grade 4 thrombocytopenia (=1) Grade 3 Fatigue (n=1)
Group D PR104 + docetaxel 75 + GCSF 1 770 6 -

McKeage et al.

McKeage et al. BMC Cancer 2012 12:496   doi:10.1186/1471-2407-12-496

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