Table 1

Odds ratio estimation to assess the association between breast cancer (BC) and DNA repair capacity (DRC) and other selected variables in women with BC (n=285) and women without BC (n=539)
Variable Women with BC n (mean) Women without BC n (mean) Crude OR1 Adjusted OR2 Pvalue
(95% CI) (95% CI)
Age (continuous)* 285 (56.7) 539 (52.4) 1.02 (1.02,1.04) 1.02 (1.01, 1.05) 0.001
Number of children 273(2.4) 517 (2.1) 1.2 (1.1, 1.3) 1.1 (1.0, 1.3) 0.055
# Missing (34)
Increasing BMI (continuous)* 284 (27.8) 534 (27.2) 1.02 (0.9, 1.1) 1.03 (1.0, 1.1) 0.118
# Missing (6)
Family history of BC
  Yes 64 78 1.7 (1.2, 2.5) 1.7 (1.0, 2.8) 0.054
  No 221 461
Marital status
  Married 154 362 Referent Referent
  Single 61 92 4.2 (2.2, 7.8) 5.9 (2.3, 15.6) <0.001
  Divorced 40 66 2.7 (1.4, 5.3) 3.6 (1.2, 10.5) 0.025
  Widow 30 17 2.9 (1.4, 5.9) 4.6 (1.6, 13.7) 0.006
# Missing (2)
Irregular menstrual cycles
  Yes 183 320 1.2 (0.9,1.6) 1.4 (0.8, 2.2) 0.207
  No 102 213
# Missing (6)
History of pregnancy
  Yes 220 401 1.2 (0.8,1.6) 1.4 (0.8,2.2) 0.382
  No 65 138
History of breastfeeding
  Yes 122 246 0.8 (0.6, 1.1) 0.8 (0.5, 1.2) 0.256
  No 118 194
# Missing (144)
Alcohol intake
  Yes 42 98 0.8 (0.6, 1.2) 0.8 (0.5, 1.7) 0.526
  No 243 441
Smoking
  Yes 37 48 1.6 (0.9, 2.4) 1.1 (0.6, 2.1) 0.707
  No 248 491

*Mean values presented in parenthesis.

Comparisons were measured with the crude1 and the adjusted2 multiple logistic regression odds ratio (OR)3 in the total sample divided by patients and women without breast cancer.

1Crude or unadjusted analysis: The analysis is carried out without taking into consideration potential confounders.

2Adjusted analysis: The analysis is carried out adjusting for the potential effect of all confounding variables simultaneously by using logistic regression model. The associations were adjusted by DRC, age, body mass index, family history of breast cancer, number of children, marital status, and/or smoking.

Matta et al.

Matta et al. BMC Cancer 2012 12:490   doi:10.1186/1471-2407-12-490

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