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Open Access Research article

The association of DNA Repair with breast cancer risk in women. A comparative observational study

Jaime Matta1*, Miguel Echenique2, Esperanza Negron1, Luisa Morales1, Wanda Vargas1, Felipe Sánchez Gaetan3, Eduardo Ramírez Lizardi4, Aníbal Torres5, Jose Ortiz Rosado6, Guillermo Bolaños7, Juan González Cruz3, Joaquín Laboy8, Ricardo Barnes8, Santos Santiago Medina9, Ángel Romero4, Rosendo Martinez3, Julie Dutil10, Erick Suarez11, Carolina Alvarez-Garriga1213 and Manuel Bayona1213

Author affiliations

1 Department of Pharmacology, Physiology, and Toxicology, Department of Surgery, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico, 00732

2 Auxilio Mutuo Hospital, San Juan, Puerto Rico

3 Department of Surgery and Damas Hospital, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

4 Private Practice, Ponce, Puerto Rico

5 Department of Surgery, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

6 Department of Surgery and Private Practice, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

7 Department of Surgery and San Lucas Hospital, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

8 Outpatient Clinics, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

9 Dr. Pila Hospital, Ponce, Puerto Rico

10 Department of Biochemistry, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

11 School of Public Health, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico

12 Public Health Program, Ponce School of Medicine and Health Sciences, Ponce, Puerto Rico

13 Current address: Division of Epidemiology/OSB/CDRH, Food and Drug Administration, Silver Spring, Maryland, USA

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Citation and License

BMC Cancer 2012, 12:490  doi:10.1186/1471-2407-12-490

Published: 22 October 2012

Abstract

Background

Previous studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community.

Methods

We conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.

Results

Compared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (p < 0.0001).

Conclusions

Our results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.

Keywords:
Breast cancer; DNA repair capacity; Association; Risk; Biomarker