Table 2

Characteristics of brain metastasis (n = 41)

Characteristic

No.(%)


Median age at diagnosis of HCC (range), years

48.5(25-82)


Median interval between diagnosis of BM from HCC (range), months

15(0-120)


Age at diagnosis of HCC (years)


< 50

23(56.1%)


≥ 50

18(43.9%)


Gender


Female

8(19.5%)


Male

33(80.5%)


Site of extracranial metastases


Lung

31(75.6%)


Bone

9(22%)


Adrenal gland

4(9.8%)


other sites

3(7.3%)


Radiological data


CT

22(53.7%)


MRI

19(46.3%)


Location of brain lesions


Supratentorial

29(70.7%)


Infratentorial

7(17.1%)


Combinations

5(12.2%)


APF (ng/ml)


< 400

15(36.6%)


≥ 400

26(63.4%)


CEA (ng/ml)


< 5

26(63.4%)


≥ 5

5(12.2%)


Unkown

10(24.4%)


CA199 (u/ml)


< 35

22(53.7%)


≥ 35

10(24.4%)


Unkown

9(22%)


Symptom


Headache

17(41.5%)


Motor weakness

14(34.1%)


Nausea

12(29.3%)


Mental change

6(14.6%)


Seizure

4(9.8%)


Visual disturbance

4(9.8%)


Cerebellar dysfunction

3(7.3%)


Aphasia

2(4.9%)


None

1(2.4%)


Interval between diagnosis of HCC and BM (months)


< 12

25(61%)


≥ 12

16(39%)


Number of brain lesions


1

24(58.5%)


2

4(9.8%)


≥ 3

13(31.7%)


Brain hemorrhage


Yes

19(46.3%)


No

22(53.7%)


KPS


90-100

6(14.6%)


80-89

7(17.1%)


70-79

12(29.3%)


60-69

9(22%)


< 60

7(17.1%)


RPA class


I

1(2.4%)


II

24(58.5%)


III

16(39.0%)


Jiang et al. BMC Cancer 2012 12:49   doi:10.1186/1471-2407-12-49

Open Data