Effects of sorafenib treatmentson cell cycle distributionof SMMC-7721 and BEL-7402. Cells were treated with 6 Gy radiation (radiation), 15 μM sorafenib 30 min before 6 Gy radiation (radiation + preradiation sorafenib), or radiation followed 24 hrs later with 15 μM sorafenib (radiation + post radiation sorafenib), or untreated (control). Fixed cells were stained with propidium iodide and analyzed for DNA content by flow cytometry. A. SMMC-7721. B. BEL-7402. Percentage of hepatocellular carcinoma cells in G2 phase. Comparisons of mean values were performed by using ANOVA. Mean ± SD (n = 3). *P < 0.05 vs. the radiation group.
Li et al. BMC Cancer 2012 12:485 doi:10.1186/1471-2407-12-485