Effect of sorafenib onDNA damage of irradiatedSMMC-7721 and BEL-7402 cells. Treated cells were stained with DAPI and anti- γ-H2AX antibody. A. Sorafenib was added to SMMC-7721 and BEL-7402 cells 30 min prior to their irradiation (6 Gy). B. Post-irradiation sorafenib treated cells were incubated for 6 h before staining. C. Percentage of cells with ≥ 10 γ-H2AX foci. Comparisons of mean values were performed using the independent two sample t test. Mean ± SD (n = 3). *P < 0.05 vs. the radiation group.
Li et al. BMC Cancer 2012 12:485 doi:10.1186/1471-2407-12-485