Clonogenic survival of humanhepatocellular carcinoma cells SMMC-7721(A, C) and BEL-7402(B, D) after irradiationwith or without sorafenib.A, B Sorafenib (15 mM) was added 30 min prior to irradiation of cells (pre-IR sorafenib). C, D. Cells were irradiated (0-10 Gy) and sorafenib was added 24 h post irradiation (post-IR sorafenib). Survival fraction (SF) was calculated by using the mean plating efficiency (PE) of untreated cells as the denominator to illustrate independent cytotoxic effects of sorafenib; linear quadratic (LQ) equation was fitted to data.
Li et al. BMC Cancer 2012 12:485 doi:10.1186/1471-2407-12-485