Figure 7.

Unsupervised cluster analysis of phospho-proteins depicts that lymphoma samples can be separated from normal PBMCs. All phospho-proteins with a relative MFI greater or less than 0.25 in the basal or induced conditions were included in the unsupervised cluster analysis. Phospho-proteins and samples were subjected to clustering using complete linkage method. The heatmap illustrates basal and induced MFI phospho-proteins in all SLL/CLL, MZL patients and PBMCs. Basal, unstimulated MFI represent a ratio of MFI in the lymphoma CD20⁺-subset and MFI in CD20⁺ normal B cells. Induced signaling are the ratio of MFI in the stimulated CD20⁺-subset or the CD5⁺ CD20^--subset in case of T cells, and MFI from unstimulated cells in the same subset. Missing data are indicated by grey color.