Low CD79b and IgM expression in SLL/CLL cells correlates with impaired aBCR-induced p-PLCγ. (A) Contour plot showing CD20 and CD79b expression in CD20+ B cells from representative normal PBMC, MZL (n=2) and SLL/CLL (n=4). (B) Bar chart illustrating expression of IgM, IgG, CD79b and CD79a as median fold change MFI ± SEM in SLL/CLL (n=6) and MZL (n=4) as fold change MFI from normal CD20+ B from PBMCs analyzed in parallel. * p < 0.05. (C) Scatter plot of p-PLCγ MFI after 4 minutes of BCR stimulation in SLL/CLL and MZL malignant CD20+ B cells on x axis and IgM or CD79b fold change MFI in SLL/CLL and MZL cells from normal CD20+ B cells on y axis.
Blix et al. BMC Cancer 2012 12:478 doi:10.1186/1471-2407-12-478