Basal and activation induced signaling in samples from lymphoma patients and healthy donors. Samples from lymphoma patients or from peripheral blood of healthy donors (PBMCs) were stimulated with various stimulation conditions (unstimulated, 4 minutes anti-(a)BCR (crosslinking with anti-IgM/anti-IgG), or 15 minutes CD40L, IL-7 or PMA/ionomycin), followed by measurement of phospho-proteins using flow cytometry. Contour plots show basal level (unstimulated) or activation-induced levels of p-PLCγ, p-p65 and p-STAT5, in a marginal lymphoma patient sample (MZL-02) and a healthy donor PBMC (PBMC-02).
Blix et al. BMC Cancer 2012 12:478 doi:10.1186/1471-2407-12-478