Table 1

Selected inflammatory genes and their association with biliary stones and cancer in the Shanghai population
Evaluated SNPs
Gene symbol (name) Gene function Chromosome location Examined in the current study Previously reported variants1 High linkage disequilibrium
IL8 (interleukin 8) Neutrophil chemotaxis 4q12-q13 rs12506479, rs10805066 rs2227543, rs7657356 rs4073, rs2227307, rs2227306 rs2227307, rs4073, rs2227543 and rs2227306 (r2>0.8)
NFKBIL (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1) Encodes divergent member of I-kappa-B family proteins 6p21.3 rs2230365, rs2239707, rs2857605, rs928815, rs13215091
RNASEL (ribonuclease L) Encodes an interferon-inducible ribonuclease 1q25 rs11807829, rs474939, rs533259, rs682585, rs627839, rs627928, rs635261, rs672527, rs579006 rs11072, rs486907 rs11807829 and rs11072 (r2=0.98), rs635261 and rs627839 (r2=0.8), rs579006 with rs486907 (r2=0.95)
TNF (tumor necrosis factor) Inflammatory cytokine that promotes hyperlipidemia by increasing hepatic triglyceride production and decreasing clearance 6p21.3 rs2857708, rs769177, rs769178 rs1800750, rs1800629, rs361525, rs673, rs1799724, rs1800630, rs1800610, rs1799964 rs769178 and rs1799724 (r2=0.95)
VEGFA (vascular endothelial growth factor A) Vascular permeability, angiogenesis, vasculogenesis, cell growth, cell migration, apoptosis 6p12 rs25648, rs3025000, rs3025033, rs3025035, rs833052, rs866236, rs9367173, rs9394963, rs998584, rs10434, rs6905288, rs6899540, rs4714696, rs833070 rs3025039 (rs3025033 and rs3025039 (r2=0.93)

1Previously reported variants associated with the risk of biliary stones and/or biliary tract caner in the Shanghai population study.

Castro et al.

Castro et al. BMC Cancer 2012 12:468   doi:10.1186/1471-2407-12-468

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