|Selected inflammatory genes and their association with biliary stones and cancer in the Shanghai population|
|Gene symbol (name)||Gene function||Chromosome location||Examined in the current study||Previously reported variants1||High linkage disequilibrium|
|IL8 (interleukin 8)||Neutrophil chemotaxis||4q12-q13||rs12506479, rs10805066 rs2227543, rs7657356||rs4073, rs2227307, rs2227306||rs2227307, rs4073, rs2227543 and rs2227306 (r2>0.8)|
|NFKBIL (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1)||Encodes divergent member of I-kappa-B family proteins||6p21.3||rs2230365, rs2239707, rs2857605, rs928815, rs13215091|
|RNASEL (ribonuclease L)||Encodes an interferon-inducible ribonuclease||1q25||rs11807829, rs474939, rs533259, rs682585, rs627839, rs627928, rs635261, rs672527, rs579006||rs11072, rs486907||rs11807829 and rs11072 (r2=0.98), rs635261 and rs627839 (r2=0.8), rs579006 with rs486907 (r2=0.95)|
|TNF (tumor necrosis factor)||Inflammatory cytokine that promotes hyperlipidemia by increasing hepatic triglyceride production and decreasing clearance||6p21.3||rs2857708, rs769177, rs769178||rs1800750, rs1800629, rs361525, rs673, rs1799724, rs1800630, rs1800610, rs1799964||rs769178 and rs1799724 (r2=0.95)|
|VEGFA (vascular endothelial growth factor A)||Vascular permeability, angiogenesis, vasculogenesis, cell growth, cell migration, apoptosis||6p12||rs25648, rs3025000, rs3025033, rs3025035, rs833052, rs866236, rs9367173, rs9394963, rs998584, rs10434, rs6905288, rs6899540, rs4714696, rs833070||rs3025039||(rs3025033 and rs3025039 (r2=0.93)|
1Previously reported variants associated with the risk of biliary stones and/or biliary tract caner in the Shanghai population study.
Castro et al.
Castro et al. BMC Cancer 2012 12:468 doi:10.1186/1471-2407-12-468