Downstream target genes of SPARC in cervical cancer cells. (A) E-cadherin, β-catenin, alpha-catenin, Integrin β3, Integrin β1, ILK, FAK, P53, P21, Cyclin D1, PCNA, Bcl-2, Bax, u-PA, uPAR, PAI-1, MMP2, MMP9, TIMP1 and TIMP2 mRNA expressions as measured by q-RT-PCR. (B) P53, P21, Cyclin D1, PCNA, Bcl-2 and Bax protein expressions in SPARC shRNA infected cells and control shRNA infected cells as measured by Western blot. (C) MMPs expressions of SPARC shRNA infected cells, control shRNA infected cells and non-infected cells as measured by zymography. *P<0.05 versus control.
Chen et al. BMC Cancer 2012 12:464 doi:10.1186/1471-2407-12-464