Effects of SPARC knockdown on tumor growth and lung metastasis in nude mice. (A) Photograph of xenografts dissected from nude mice after subcutaneous inoculation (n=4). (B) Tumor growths of SPARC shRNA infected cells, control shRNA infected cells and non-infected cells observed continuously for 8 weeks. (C) H&E staining photos of xenografts dissected from nude mice after subcutaneous inoculation. (D) Photograph of lung metastasis through a microscope after inoculation through tail vein. (n=8) (Magnification ×200). *P<0.05 versus control.
Chen et al. BMC Cancer 2012 12:464 doi:10.1186/1471-2407-12-464