Apoptosis-related protein expressions. The expression of apoptotic proteins in glioblastoma cells stimulated with PMA prior to parthenolide treatment was assessed by western blotting. Representative blots are shown. (A) Analysis showed that parthenolide decreased the protein expression of Bcl-2 and increased the protein expression of Bak and Bax in a dose-dependent fashion. (B) Analysis showed that parthenolide induced the activation of caspase-3 and −9 in a dose-dependent manner.
Nakabayashi and Shimizu BMC Cancer 2012 12:453 doi:10.1186/1471-2407-12-453