|Hazard Ratios (HRs) and 95% confidence intervals (CIs) of hepatocellular carcinoma (HCC) according to hepatitis B and C virus infection status|
|Infection status||No. of subjects||Person-years||No. of HCC||HRa(95% CI)|
|HBsAg(−) / anti-HCV(−)||5744||53,504||16||1.0 (reference)|
|HBsAg(+) / anti-HCV(−)||335||2,981||15||17.1 (8.4-34.8)|
|HBsAg(−) / anti-HCV(+)||360||3,731||12||10.4 (4.9-22.1)|
|HBsAg(+) / anti-HCV(+)||14||133||3||115.0 (32.5-407.3)|
|SI and 95% CI: 4.5 (1.3-15.5)b|
HBsAg, hepatitis B surface antigen; anti-HCV, antibodies against hepatitis C virus. aHR: age- and sex-adjusted. bSI: synergy index=(RR11-1)/(RR01+RR10-2), in which RR11=relative risk of the joint effect of two risk factors; RR01 and RR10=relative risk of each risk factor in the absence of the other. Two hundred and forty-one subjects including 4 HCC cases had no information on HBsAg or anti-HCV, and were excluded from the analysis.
Oh et al.
Oh et al. BMC Cancer 2012 12:452 doi:10.1186/1471-2407-12-452