Table 2

Relative risks (RRs) and 95% confidence intervals (CIs) of hepatocellular carcinoma (HCC) according to selected characteristics
Person-years No. of HCC Crude RR (95% CI) Adjusted HRa(95% CI) Adjusted HRb(95% CI)
HBsAg
Negative 57,319 28 1.0 (reference) 1.0 (reference) 1.0 (reference)
Positive 3,115 18 12.0 (6.6-21.7) 12.5 (6.9-22.7) 13.3 (7.3-24.4)
Unknown 2,737 4 2.7 (0.9-7.8) 2.4 (0.8-7.0) 0.1 (0.01-0.5)
Anti-HCV
Negative 56,516 31 1.0 (reference) 1.0 (reference) 1.0 (reference)
Positive 3,880 15 6.9 (3.7-12.7) 7.0 (3.8-13.1) 6.7 (3.6-12.6)
Unknown 2,774 4 2.5 (0.9-7.0) 2.3 (0.8-6.5) 0.1 (0.01-0.4)
FBS (mg/dL)
<100 26,930 15 1.0 (reference) 1.0 (reference)
100-126 11,737 11 1.6 (0.7-3.5) 1.6 (0.7-3.4)
≥126 5,746 6 1.8 (0.7-4.6) 1.6 (0.6-4.1)
Unknown 18,757 18 1.7 (0.9-3.4) 1.7(0.9-3.4)
AST (U/L)
<35 48,247 11 1.0 (reference) 1.0 (reference)
≥35 11,890 36 13.5 (6.9-26.6) 11.3 (5.7-22.5)
Unknown 3,033 3 3.8 (1.0-13.8) 3.6 (0.99-13.2)
ALT (U/L)
<30 47,841 15 1.0 (reference) 1.0 (reference)
≥30 12,374 32 8.5 (4.6-15.7) 8.3 (4.4-15.6)
Unknown 2,955 3 2.8 (0.8-9.9) 2.8 (0.8-9.9)
Alcohol drinking (g/day)
0-23.9 51,193 30 1.0 (reference) 1.0 (reference)
≥24 7,214 16 3.8 (2.1-7.0) 2.2 (1.1-4.4)
Unknown 4,763 4 1.4 (0.5-4.0) 1.0 (0.3-2.8)
Tobacco smoking
Never smoker 40,375 20 1.0 (reference) 1.0 (reference)
Past smoker 4,826 7 3.1 (1.3-7.3) 1.2 (0.4-3.3)
Current smoker 17,638 23 2.7 (1.5-4.8) 1.3 (0.6-2.6)
Unknown 331 0 - -
Body mass index (kg/m2)
<18.5 2,463 2 0.8 (0.2-3.5) 0.72(0.17-3.06)
18.5-22.9 25,634 25 1.0 (reference) 1.0 (reference)
23.0-24.9 15,241 8 0.5 (0.2-1.2) 0.6 (0.3-1.4)
≥25.0 18,780 13 0.7 (0.4-1.4) 0.96 (0.5-1.9)
Unknown 1,052 2 2.1 (0.5-8.7) 2.2 (0.5-9.5)
History of acupuncture
Never 27,378 27 1.0 (reference) 1.0 (reference)
Ever 27,998 20 0.8 (0.4-1.4) 0.8 (0.5-1.5)
Unknown 7,794 3 0.4 (0.1-1.3) 0.5 (0.2-1.7)
History of transfusion
No 40,673 31 1.0 (reference) 1.0 (reference)
Yes 2,132 2 1.3 (0.3-5.4) 1.5 (0.4-6.4)
Unknown 20,365 17 0.98 (0.5-1.8) 1.1 (0.6-2.0)

HBsAg, hepatitis B surface antigen; anti-HCV, antibodies against hepatitis C virus; FBS, fasting blood sugar; ALT, alanine aminotransferase; AST, aspartate aminotransferase. aAge- and sex-adjusted. bAge-, sex- and HBsAg/anti-HCV positivity-adjusted.

Oh et al.

Oh et al. BMC Cancer 2012 12:452   doi:10.1186/1471-2407-12-452

Open Data