Table 1

Effects of 5-FU on the development of colon tumors in the KAD rat
Treatment No. of rats Macroscopic observation Microscopic observation
Multiplicity Volume (mm3)1 Multiplicity Volume (mm3)2
adenomas adenocarcinomas total adenocarcinoma
Saline 9 5.56 ± 3.43 106.34 ± 68.92 3.11 ± 2.52 3.22 ± 2.77 6.33 ± 4.87 63.85 ± 51.06
50 mg/kg 5-FU 9 6.33 ± 3.04 77.28 ± 57.23 3.78 ± 1.79 2.33 ± 1.94 6.11 ± 2.37 34.40 ± 31.26 3

1Tumor volume was determined by the formula V = a × b2/2 (V: volume. a: the largest superficial diameter and b: the smallest superficial diameter).

2Volumes of adenomas were too small to calculate.

3Adenocarcinoma volumes observed in the 5-FU-treated KAD rats were significantly reduced as compared with those of non-treated rats (p <0.02).

Yoshimi et al.

Yoshimi et al. BMC Cancer 2012 12:448   doi:10.1186/1471-2407-12-448

Open Data