Experimental schedule. KAD rats at 5 weeks of age were given a subcutaneous injection of AOM at 20 mg/kg body weight (arrow head). One week after the AOM injection they were given 2% DSS (MW 36,000–50,000) in their drinking water for one week (black box). Endoscopic observation was carried out at week 8 (open arrow). 5-FU was administrated intravenously at weeks 9, 10, 11, 13, 14 and 15 (arrows). All animals were sacrificed at week 16.
Yoshimi et al. BMC Cancer 2012 12:448 doi:10.1186/1471-2407-12-448