Open Access Highly Accessed Case report

Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: Increased expression of a CD44 variant isoform after chemotherapy

Go J Yoshida, Yasushi Fuchimoto*, Tomoo Osumi, Hiroyuki Shimada, Seiichi Hosaka, Hideo Morioka, Makio Mukai, Yohei Masugi, Michiie Sakamoto and Tatsuo Kuroda

BMC Cancer 2012, 12:444  doi:10.1186/1471-2407-12-444

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Ectopic or Drastic Increase of CSCs after Chemotherapy

Go Yoshida   (2014-11-06 09:59)  Tokyo Medical and Dental University email

As shown in Figure-4 of this case report, conventional chemotherapy is considered to be partially responsible for the increase of cancer stem cells (CSCs) in number in vivo. The recent Nature article entitled as “Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function” investigated into the drastic proliferation of mutant KRAS-driven pancreatic ductal adenocarcinoma CSCs utilizing the Tet-ON/OFF and ON system. Notably, they have also revealed the metabolic features of CSCs to depend more on mitochondria as compared with non-CSCs or before oncogene ablation.

Ref: Nature 514, 628–632 (30 October 2014)

Competing interests

No competing interests exist.


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