Table 6

Analysis of gene-gene interactionsof CYP1A1 MspI, GSTM1 present/null, GSTT1 present/null, and GSTP1 Ile105Val polymorphisms in lungcancer risk
N° of at-risk alleles Cases n Controls Unadjusted AdjustedaOR p-interaction
(%) n (%) OR [95% CI] [95% CI]
CYP1A1-GSTM1
T/T-present/present 283 (36.7) 286 (37.0) Reference Reference 0.923
T/T->=1 null allele 90 (11.7) 70 (9.1) 1.30 [0.91-1.85] 1.18 [0.80-1.76]
T/C+C/C-present/present 308 (40.0) 332 (43.0) 0.94 [0.75-1.18] 0.95 [0.74-1.23]
T/C+C/C->=1 null allele 89 (11.6) 84 (10.9) 1.07 [0.76-1.51] 1.07 [0.73-1.59]
CYP1A1-GSTT1
T/T-present/present 461 (59.9) 490 (63.5) Reference Reference 0.185
T/T->=1 null allele 152 (19.7) 120 (15.5) 1.35 [1.03-1.77] 1.26 [0.92-1.72]
T/C+C/C-present/present 130 (16.9) 128 (16.6) 1.08 [0.82-1.42] 0.95 [0.69-1.29]
T/C+C/C->=1 null allele 27 (3.5) 34 (4.4) 0.84 [0.50-1.42] 0.77 [0.43-1.37]
CYP1A1-GSTP1
T/T-Ile/Ile 277 (35.3) 266 (33.8) Reference Reference 0.916
T/T-Ile/Val+Val/Val 75 (9.5) 64 (8.1) 1.16 [0.80-1.70] 1.14 [0.74-1.75]
T/C+C/C-Ile/Ile 327 (41.7) 363 (46.1) 0.86 [0.68-1.08] 0.83 [0.64-1.07]
T/C+C/C-Ile/Val+Val/Val 106 (13.5) 95 (12.1) 1.08 [0.78-1.50] 0.93 [0.64-1.34]
GSTM1-GSTT1
present/present-present/present 304 (39.2) 276 (35.6) Reference Reference 0.041
present/present->=1 null allele 71 (9.1) 82 (10.6) 0.79 [0.55-1.12] 0.65 [0.43-0.97]
>=1 null allele-present/present 314 (40.5) 335 (43.2) 0.85 [0.68-1.07] 0.85 [0.66-1.10]
>=1 null allele->=1 nullallele 87 (11.2) 83 (10.7) 0.95 [0.68-1.34] 0.92 [0.62-1.35]
GSTM1-GSTP1
present/present- Ile/Ile 161 (20.8) 146 (19.0) Reference Reference 0.493
present/present- Ile/Val+Val/Val 212 (27.4) 209 (27.1) 0.92 [0.69-1.24] 0.88 [0.63-1.23]
>=1 null allele- Ile/Ile 184 (23.8) 175 (22.7) 0.95 [0.70-1.29] 1.01 [0.71-1.42]
>=1 null allele- Ile/Val+Val/Val 216 (27.9) 240 (31.2) 0.81 [0.61-1.09] 0.79 [0.57-1.10]
GSTT1-GSTP1
present/present- Ile/Ile 276 (35.7) 256 (33.2) Reference Reference 0.880
present/present- Ile/Val+Val/Val 341 (44.1) 352 (45.7) 0.90 [0.72-1.13] 0.81 [0.63-1.05]
>=1 null allele- Ile/Ile 69 (8.9) 65 (8.4) 0.98 [0.67-1.44] 0.79 [0.51-1.21]
>=1 null allele- Ile/Val+Val/Val 87 (11.2) 97 (12.6) 0.83 [0.59-1.16] 0.72 [0.49-1.05]

a Adjusted by age, pack-years (non-smoker, <37PY, ≥37PY), family history of any cancer, and worker in list A occupation*.

* List A includes occupations known to be associated with lung cancer.

López-Cima et al.

López-Cima et al. BMC Cancer 2012 12:433   doi:10.1186/1471-2407-12-433

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