Table 4

Analysis of interaction betweenpolymorphisms and tobacco consumptionin lung cancer risk
Cases/Controls n(%)/n(%) pa Unadjusted Adjustedb p-interaction
OR [95% CI] OR [95% CI]
CYP1A1 * PY
T/T–Non-smokers 40(5.1)/182(23.1) <0.001 Reference Reference 0.071
T/C+C/C–Non-smokers 11(1.4)/40(5.1) 1.25 [0.59-2.65] 1.16 [0.59-2.52]
T/T–Smokers<37PY 139(17.6)/262(33.2) 2.41 [1.61-3.62] 2.47 [1.64-3.71]
T/C+C/C–Smokers<37PY 32(4.1)/77(9.8) 1.89 [1.10-3.25] 1.83 [1.06-3.17]
T/T–Smokers>=37PY 429(54.4)/187(23.7) 10.44 [6.78-16.07] 10.14 [6.46-14.99]
T/C+C/C–Smokers>=37PY 138(17.5)/40(5.1) 15.70 [8.52-28.94] 15.38 [9.32-25.38]
GSTM1 * PY
present/present–Non-smokers 26(3.3)/102(13.2) <0.001 Reference Reference 0.544
>=1 null allele–Non-smokers 25(3.2)/119(15.3) 0.82 [0.45-1.52] 0.82 [0.44-1.52]
present/present–Smokers<37PY 70(9.0)/149(19.2) 1.84 [1.09-3.10] 1.87 [1.10-3.17]
>=1 null allele–Smokers<37PY 96(12.4)/182(23.5) 2.07 [1.25-3.42] 2.10 [1.26-3.51]
present/present–Smokers>=37PY 279(35.9)/106(13.7) 10.33 [5.98-17.84] 10.27 [6.24-16.84]
>=1 null allele–Smokers>=37PY 280(36.0)/117(15.1) 9.39 [5.49-16.05] 9.00 [5.49-14.73]
GSTT1 * PY
present/present–Non-smokers 40(5.1)/185(23.9) <0.001 Reference Reference 0.060
>=1 null allele–Non-smokers 11(1.4)/36(4.6) 1.41 [0.66-3.02] 1.44 [0.67-3.09]
present/present–Smokers< 37PY 129(16.6)/264(34.1) 2.26 [1.50-3.40] 2.31 [1.53-3.50]
>=1 null allele–Smokers< 37PY 37(4.8)/67(8.6) 2.55 [1.49-4.38] 2.62 [1.52-4.50]
present/present–Smokers>=37PY 449(57.9)/161(20.8) 12.90 [8.25-20.17] 12.72 [8.55-18.91]
>=1 null allele–Smokers>=37PY 110(14.2)/62(8.0) 8.21 [4.85-13.87] 8.05 [5.02-12.91]
GSTP1 * PY
Ile/Ile – Non-smokers 22(2.8)/93(11.8) <0.001 Reference Reference 0.344
Ile/Val+Val/Val – Non-smokers 29(3.7)/127(16.1) 0.97 [0.52-1.79] 0.95 [0.51-1.78]
Ile/Ile–Smokers< 37PY 84(10.7)/141(17.9) 2.52 [1.46-4.36] 2.69 [1.55-4.66]
Ile/Val+Val/Val–Smokers<37PY 87(11.0)/199(25.3) 1.85 [1.08-3.15] 1.79 [1.04-3.08]
Ile/Ile–Smokers > =37PY 246(31.2)/95(12.1) 10.95 [6.06-19.76] 10.64 [6.24-18.15]
Ile/Val+Val/Val–Smokers>=37PY 320(40.6)/132(16.8) 10.25 [5.85-19.95] 10.05 [5.98-16.90]

a Chi-squared p-value.

b Adjusted by age, family history of any cancer, and worker in list A occupation*.

* List A includes occupations known to be associated with lung cancer.

López-Cima et al.

López-Cima et al. BMC Cancer 2012 12:433   doi:10.1186/1471-2407-12-433

Open Data