Table 2

Associations of measures of patterns of sunlight exposure in BCC and SCC cases and controls
Controls (n = 316) Basal cell carcinoma (n = 218) Squamous cell carcinoma (n = 169)
Variable n (%) n (%) OR (95% CI)1 OR (95% CI)2 n (%) OR (95% CI)1 OR (95% CI)2
Blistering Sunburn
No 101 (32.3) 54 (25.0) 1.00 (reference) 1.00 (reference) 38 (23.0) 1.00 (reference) 1.00 (reference)
Yes 212 (67.7) 162 (75.0) 1.96 (1.27-3.03) 1.56 (0.96-2.54) 127 (77.0) 2.02 (1.22-3.33) 1.24 (0.71-2.18)
Job in sun ≥3 months
No 227 (72.8) 120 (55.3) 1.00 (reference) 1.00 (reference) 86 (51.8) 1.00 (reference) 1.00 (reference)
Yes 85 (27.2) 97 (44.7) 1.38 (0.89-2.14) 1.31 (0.81-2.12) 80 (48.2) 1.73 (1.06-2.83) 1.72 (0.99-2.97)
# years with job
≤10 57 (18.7) 47 (22.3) 1.17 (0.70-1.94) 1.07 (0.61-1.86) 44 (27.0) 1.64 (0.94-2.86) 1.64 (0.88-3.07)
>10 21 (6.9) 44 (20.9) 2.14 (1.12-4.11) 2.12 (1.05-4.27) 33 (20.2) 2.54 (1.23-5.28) 2.36 (1.07-5.20)
ptrend = 0.03 ptrend = 0.06 ptrend = 0.01 ptrend = 0.02
Lifetime tanning bed use 209 (71.3) 175 (82.5) 1.00 (reference) 1.00 (reference) 127 (80.9) 1.00 (reference) 1.00 (reference)
Never used 44 (15.0) 25 (11.8) 0.99 (0.56-1.76) 0.99 (0.53-1.82) 18 (11.5) 1.01 (0.52-1.98) 0.80 (0.38-1.71)
1–10 times 40 (13.7) 12 (5.7) 0.64 (0.30-1.36) 0.64 (0.30-1.36) 12 (7.6) 1.67 (0.75-3.73) 1.85 (0.74-4.62)
>10 times ptrend = 0.32 ptrend = 0.20 ptrend = 0.29 ptrend = 0.40
Apply SPF3 ≥15
Always/often 124 (39.6) 82 (37.8) 1.00 (reference) 1.00 (reference) 53 (32.5) 1.00 (reference) 1.00 (reference)
Sometimes 98 (31.3) 59 (27.2) 0.79 (0.50-1.26) 0.87 (0.52-1.45) 56 (34.4) 0.83 (0.49-1.42) 0.86 (0.47-1.59)
Rarely/never 91 (29.1) 76 (35.0) 0.83 (0.52-1.32) 0.93 (0.56-1.54) 54 (33.1) 0.79 (0.46-1.36) 0.87 (0.48-1.60)
Cumulative sunlight exposure
Low 87 (32.3) 52 (27.4) 1.00 (reference) 1.00 (reference) 35 (22.7) 1.00 (reference) 1.00 (reference)
Medium 92 (34.2) 54 (28.4) 1.02 (0.61-1.69) 1.42 (0.81-2.50) 57 (37.0) 1.49 (0.84-2.64) 2.36 (1.22-4.57)
High 90 (33.5) 84 (44.2) 1.37 (0.83-2.27) 1.88 (1.07-3.31) 62 (40.3) 1.59 (0.88-2.87) 2.47 (1.25-4.91)
Intermittent sunlight exposure
Low 91 (33.8) 80 (42.1) 1.00 (reference) 1.00 (reference) 59 (38.3) 1.00 (reference) 1.00 (reference)
Medium 84 (31.2) 52 (27.4) 0.99 (0.60-1.64) 1.26 (0.72-2.22) 46 (29.9) 1.25 (0.71-2.20) 1.58 (0.83-3.00)
High 94 (34.9) 58 (30.5) 1.15 (0.70-1.88) 1.23 (0.72-2.10) 49 (31.8) 1.48 (0.85-2.58) 1.57 (0.83-2.94)
Patterns by age at exposure
Teens
<1 hour 18 (6.0) 12 (6.0) 1.00 (reference) 1.00 (reference) 4 (2.5) 1.00 (reference) 1.00 (reference)
Continuous hours 151 (50.0) 113 (56.8) 1.04 (0.45-2.41) 0.97 (0.38-2.48) 96 (60.4) 2.33 (0.69-7.90) 1.76 (0.48-6.47)
Intermittent hours 133 (44.0) 74 (37.2) 1.08 (0.46-2.54) 1.10 (0.42-2.83) 59 (37.1) 2.26 (0.66-7.78) 1.86 (0.50-6.94)
Twenties
<1 hour 34 (11.3) 18 (9.0) 1.00 (reference) 1.00 (reference) 11 (6.9) 1.00 (reference) 1.00 (reference)
Continuous hours 102 (33.9) 91 (45.5) 1.36 (0.68-2.71) 1.58 (0.75-3.36) 74 (46.5) 2.01 (0.86-4.67) 2.99 (1.19-7.48)
Intermittent hours 165 (54.8) 91 (45.5) 1.30 (0.66-2.56) 1.56 (0.74-3.26) 74 (46.5) 2.11 (0.92-4.88) 3.15 (1.27-7.83)
Thirties
<1 hour 60 (20.5) 27 (13.6) 1.00 (reference) 1.00 (reference) 18 (11.3) 1.00 (reference) 1.00 (reference)
Continuous hours 85 (29.0) 79 (39.9) 1.31 (0.72-2.40) 1.77 (0.90-3.49) 69 (43.4) 1.55 (0.77-3.10) 2.25 (1.02-4.94)
Intermittent hours 148 (50.5) 92 (46.5) 1.38 (0.79-2.41) 2.09 (1.11-3.93) 72 (45.3) 1.47 (0.76-2.85) 1.95 (0.92-4.12)
Past 10 years
<1 hour 63 (28.6) 52 (30.2) 1.00 (reference) 1.00 (reference) 49 (33.1) 1.00 (reference) 1.00 (reference)
Continuous hours 74 (33.6) 83 (48.3) 0.88 (0.51-1.52) 1.14 (0.62-2.12) 64 (43.2) 0.81 (0.46-1.42) 1.35 (0.69-2.64)
Intermittent hours 83 (37.7) 37 (21.5) 0.57 (0.32-1.03) 0.67 (0.35-1.28) 35 (23.6) 0.60 (0.33-1.10) 0.93 (0.46-1.89)

1Odds ratios (OR) and 95% confidence intervals (CI) adjusted for age, gender, education, and history of ever smoking.

2OR and 95% CI adjusted for age, gender, education, history of ever smoking, ethnicity, eye and hair color, cutaneous sensitivity and tanning ability to sunlight exposure.

3SPF = sun protection factor.

Iannacone et al.

Iannacone et al. BMC Cancer 2012 12:417   doi:10.1186/1471-2407-12-417

Open Data