Table 6

Patients’ characteristics stratified by Copy number alternation of PIC3CA
Variable Copy number of PIK3CA (Not Amplified n = 78) Copy number of PIK3CA (Amplification n = 37) P value
Age: mean ± SD 64.8 ± 11.6 65.6 ± 9.9 0.60*
Sex: Male/Female 63 / 15 30 / 7 0.96
Number of metastatic
Lymph nodes: 0/0/1.5 0/0/0 0.65
25%/50%/75%
Primary site 0.39
Oropharyngeal 15(19.2%) 10(27.0%)
Hypopharyngeal 16(20.5%) 9(24.3%)
Laryngeal 15(19.2%) 8(21.6%)
Oral cavity 22(28.2%) 9(24.3%)
Nasal cavity 10(12.8%) 1(2.7%)
Tumor grade: 28/35/15 18/12/7 0.37
well/ moderate/poor (35.9%/44.9%/19.2%) (48.6%/32.4%/18.9%)
TNM classification
T stage: T1/T2/T3/T4 12/30/17/19 4/15/10/8 0.85
(15.3%/38.5%/21.8%/24.4%) (10.8%/40.5%/ 27.0%/21.6%)
N stage: N0/N1/N2 43/12/23 16/5/16 0.34
(55.1%/15.4%/29.5%) (43.2%/13.5%/43.2%)
Stage : I/ II/III/IV 11/16/17/34 1/7/9/20 0.28
(14.1%/20.5%/21.8%/43.6%) (2.7%/18.9%/ 24.3%/54.1%)
Pack-year(tobacco) mean ± SD 19.6 ± 24.3 22.3 ± 24.6 0.64*

* Student t test † Chi-square test ‡ Fisher test.

The patients’ characteristics stratified by the PIK3CA copy number alteration. There was no significant association.

Suda et al.

Suda et al. BMC Cancer 2012 12:416   doi:10.1186/1471-2407-12-416

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