Table 4

HNSCC gene mutations
No Nucleotide change Amino acid Change Primary tumor Exon Smoking (pack/year) Age/Sex
12 Substitution of G for C at nucleotide 35 G12A Oral Cavity (T3N0M0) KRAS Exon1 45 51/M
21 Substitution of G for C at nucleotide 35 G12A Oropharyngeal (T2N0M0) KRAS Exon1 10 47 /M
30 Substitution of G for C at nucleotide 35 G12A Oral Cavity (T3N1M0) KRAS Exon1 0 54/M
10 Substitution of A for G at nucleotide 3140 H1047R Laryngeal (T3N0M0) PIK3CA Exon20 0 61/M
51 Substitution of G for A at nucleotide 1633 E545K Oral Cavity (T1N1M0) PIK3CA Exon9 0 79/M
53 Substitution of G for A at nucleotide 1633 E545K Oral Cavity (T3N0M0) PIK3CA Exon9 0 82/M

We sequenced KRAS exon 1, BRAF exon 15 and PIK3CA exon 9 and exon 20 and identified mutations in six of the 115 patients (5.2%).

Suda et al.

Suda et al. BMC Cancer 2012 12:416   doi:10.1186/1471-2407-12-416

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