Table 1

Genes modulated by simvastatin in PC3 cells as identified by qRT-PCR arrays
GeneBank Symbol Description Change (X fold)
NM_030693 Atf5 Activating transcription factor 5 2.0↓
NM_009741 Bcl2 B-cell leukemia/lymphoma 2 2.0↓
NM_009743 Bcl2l1/2 Bcl2-like 1 and 2 1.7↓
NM_013479 Bcl2l10 Bcl2-like 10 2.0↓
NM_008670 Birc1a Baculoviral IAP repeat-containing 1a 2.4↑
NM_007464 Birc3 Baculoviral IAP repeat-containing 3 1.6↑
NM_009689 Birc5 Baculoviral IAP repeat-containing 5 3.0↑
NM_009807 Casp1 Caspase 1 2.8↑
NM_007702 Cidea Cell death-inducing DNA fragmentation factor, alpha subunit-like effector A 1.6↑
NM_010015 Dad1 Defender against cell death 1 2.5↓
NM_010175 Fadd Fas (TNFRSF6)-associated via death domain 2.0↑
NM_010177 Fasl Fas ligand (TNF superfamily, member 6) 1.9↑
NM_010548 Il10 Interleukin 10 1.6↑
NM_010712 Lhx4 LIM homeobox protein 4 3.3↓
NM_080637 Nme5 Non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) 1.8↓
NM_030152 Nol3 Nucleolar protein 3 (apoptosis repressor with CARD domain) 1.6↓
NM_023258 Pycard PYD and CARD domain containing 2.0↓
NM_013693 Tnf Tumor necrosis factor 3.2↑
NM_020275 Tnfrsf10b Tumor necrosis factor receptor superfamily, member 10b 1.6↑
NM_011611 Cd40 CD40 antigen 3.5↑
NM_009425 Tnfsf10 Tumor necrosis factor (ligand) superfamily, member 10 1.6↑
NM_011617 Cd70 CD70 antigen 3.3↑
NM_009421 Traf1 Tnf receptor-associated factor 1 4.0↑
NM_021897 Trp53inp1 Transformation related protein 53 inducible nuclear protein 1 3.2↑

Goc et al.

Goc et al. BMC Cancer 2012 12:409   doi:10.1186/1471-2407-12-409

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