Simvastatin modulates expression of Fas-L, Traf1 and cleaved caspase 8 in prostate tumor xenografts. (A) Western blots showing protein expression of Fas-L, Nme5, Traf1, cleaved caspase 8 and Trp53inp1 in PC3 cell tumor xenografts treated with simvastatin, compared to control saline treated tumors. (B) Bar graph showing quantification of the above data by densitometry analysis normalized to β-actin. Increased protein expression of Traf1, Fas-L, Trp53np1 and cleaved caspase-8 as well as decreased protein expression of Bcl-2 and Nme5 with simvastatin treatment, but not with docetaxel, compared to control is evident. The data are presented as mean ± SD (n=4 of quadruplicate experiments).
Goc et al. BMC Cancer 2012 12:409 doi:10.1186/1471-2407-12-409