Simvastatin modulates expression of pro-apoptotic extrinsic pathway proteins in PC3 cells. (A) Western blots showing protein expression of Fas-L, Nme5, Traf1, cleaved caspase-8 and Trp53inp1 in PC3 cells treated with simvastatin or docetaxel, compared to control saline treated cells. (B) Bar graph showing quantification of the above data by densitometry analysis normalized to β-actin. Increase in the protein expression of Traf1, Fas-L and Trp53np1 as well as decreased protein expression of Bcl-2 and Nme5 was observed with simvastatin treatment, but not with docetaxel, compared to control. The data are presented as mean ± SD (n=4 of quadruplicate experiments).
Goc et al. BMC Cancer 2012 12:409 doi:10.1186/1471-2407-12-409