Figure 5.

Over-expression with Bcl-2 or DN-caspase 9 does not rescue the simvastatin induces apoptosis in prostate tumor cells. (A) Bar graph showing caspase-9 activity in PC3 cells after 24 h treatment with simvastatin, docetaxel or a combination of both, compared to saline treated control. (B) Bar graph showing caspase-9 activity in PC3 cells over-expressing Bcl-2, DN-caspase 9 and both, compared to vector control in the presence and absence of 24h treatment with simvastatin. (C) Western blots showing protein expression of Bcl-2 and caspase-9 in PC3 cells over-expressing Bcl-2, DN-caspase 9 and both. (D) Bar graph showing apoptosis of PC3 cells over-expressing Bcl-2, DN-caspase 9 and both, compared to vector control in the presence and absence of 24h treatment with simvastatin. The data are presented as mean ± SD (n=4 of quadruplicate experiments).

Goc et al. BMC Cancer 2012 12:409   doi:10.1186/1471-2407-12-409
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