Figure 4.

Simvastatin induces apoptosis in prostate tumor cells in vivo via inhibition of intrinsic cell survival pathway. (A) Western blots showing reduced phosphorylation of Bad, reduced protein expression of Bcl-2 and Bcl-xL, increased release of cytochrome-c from the mitochondria as well as increased protein expression of BimL/BimS, cleaved caspase 9 and cleaved caspase 3 with 14 day simvastatin treatment, compared to saline control in PC3 cell nude mice tumor xenogafts (B) Bar graph showing quantification of the above data by densitometry analysis normalized to β-actin. The data are presented as mean ± SD (n=4 of quadruplicate experiments).

Goc et al. BMC Cancer 2012 12:409   doi:10.1186/1471-2407-12-409
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