Table 4

Serum level of nine serum biomarkers in colon cancer patients in comparison to adenoma cases and healthy control patients
Colon cancer patients (n = 164) Control patients (n = 119) Adenoma patients (n = 34)
CEA ‡ (ng/mL) median 1.26 0.51 0.82
inter-quartile range 0.54 – 4.01 0.36 -1.09 0.41 – 1.34
range 0.08 - 444.32 0.14 - 6.05 0.12 - 3.62
p-value < 0.0001
IL-8 ‡ (pg/mL) median 27.46 20.47 19.97
inter-quartile range 20.20 – 42.36 16.78 – 26.21 16.20 – 26.52
range 0.00 - 572.58 0.00 - 221.15 0.00 - 158.39
p-value < 0.0001
VEGF ‡ (pg/mL) median 77.99 59.94 67.86
inter-quartile range 46.78 – 120.94 34.99 – 98.70 42.95 – 91.41
range 5.02 - 350.38 7.54 - 427.56 10.68 - 178.72
p-value 0.02
M-CSF ‡ (pg/mL) median 8.27 7.18 6.65
inter-quartile range 6.70 – 12.76 5.31 – 10.26 5.47 – 8.58
range 2.26 - 58.23 2.99 - 72.86 3.50 - 30.55
p-value 0.02
S100A11 ‡ (ng/mL) median 12.14 10.89 11.93
inter-quartile range 9. 39 – 15.46 7.97 – 14.18 9.61 – 16.05
range 4.37 - 177.68 3.99 - 105.25 6.69 - 56.93
p-value 0.04
NNMT (ng/mL) median 1.48 1.46 1.63
inter-quartile range 0.72 – 4.23 0.67 – 4.60 0.64 – 7.82
range 0.25 - 70.00* 0.27 - 70.00* 0.28 - 70.00*
p-value > 0.05
C3a desArg ‡ (ng/mL) median 708 808 660
inter-quartile range 514 – 906 538 – 1134 344 – 1216
range 140 - 6114 150 - 3316 200 - 3282
p-value 0.04
CD26 ‡ (ng/mL) median 442 550 614
inter-quartile range 378 – 582 428 – 698 494 – 750
range 184 - 1352 0.00 - 1034 82 – 3980*
p-value 0.0002
CRP ‡ (ng/mL) median 4018 2086 2020
inter-quartile range 1718 – 9238 1188 – 5260 1208 – 4768
range 778 - 59800* 726 - 59800* 902 - 59800*
p-value 0.006

*Detection Limit, ‡ Comparison of medium serum levels between colon cancer patients and control patients p < 0.05.

Bünger et al.

Bünger et al. BMC Cancer 2012 12:393   doi:10.1186/1471-2407-12-393

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