Table 6

Comparison of Diagnostic Results of NAB alone and NAB combined with Tumor Markers according to histological subtype
Diagnostic Method Sensitivity(%) Specificity(%) Accuracy(%) PPV (%) NPV (%)
Adencarcinoma subtype (n=92)
NAB alone 79.3 100 87.1 100 74.3
NAB+Serum Tumor marker
CYFRA (3.3) 81.5 81.8 81.6 88.2 72.6
CEA (5) 81.5 90.9 85 93.8 74.6
SCC (2) 79.3 92.7 84.4 94.8 72.9
NAB+Cytological Tumor marker
CYFRA (15.7) 92.4 98.2 94.6 98.8 88.5
CEA (0.6) 89.1 92.7 90.5 95.3 83.6
SCC (0.86) 83.5 70.9 81.6 88 78
Squamous cell carcinoma subtype (n=29)
NAB alone 89.7 100 96.4 100 94.8
NAB+Serum Tumor marker
CYFRA (3.3) 93.1 81.8 85.7 73 95.7
CEA (5) 93.1 90.9 91.7 84.4 96.2
SCC (2) 93.1 92.7 92.9 87.1 96.2
NAB+Cytological Tumor marker
CYFRA (15.7) 100 98.2 98.8 96.7 100
CEA (0.6) 96.6 92.7 94 87.5 98.1
SCC (0.86) 100 70.9 81 64.4 100

Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL.

Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy.

Hur et al.

Hur et al. BMC Cancer 2012 12:392   doi:10.1186/1471-2407-12-392

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