Table 5

Comparison of Diagnostic Results of NAB alone and NAB combined with Tumor Markers according to tumor stage
Diagnostic Method Sensitivity (%) Specificity (%) Accuracy (%) PPV (%) NPV (%)
Early Stage (Stage 1 and 2, n=55)
NAB alone 75.9 100 88.1 100 80.9
NAB+Serum Tumor marker
CYFRA (3.3) 77.8 81.8 79.8 80.8 78.9
CEA (5) 75.9 90.9 83.5 89.1 79.4
SCC (2) 75.9 92.7 84.4 91.1 79.7
NAB+Cytological Tumor marker
CYFRA (15.7) 94.4 98.2 96.3 98.1 94.7
CEA (0.6) 87 92.7 89.9 92.2 87.9
SCC (0.86) 87 70.9 78.9 74.6 84.8
Advanced Stage (Stage 3 and 4, n=84)
NAB alone 88.1 100 92.8 100 84.6
NAB+Serum Tumor marker
CYFRA (3.3) 90.5 81.8 87.1 88.4 84.9
CEA (5) 92.9 90.9 92.1 94 89.3
SCC (2) 89.3 92.7 90.6 94.9 85
NAB+Cytological Tumor marker
CYFRA (15.7) 95.2 98.2 96.4 98.8 93.1
CEA (0.6) 95.2 92.7 94.2 95.2 92.7
SCC (0.86) 94 70.9 84.9 83.2 88.6

Note-Numbers in parentheses are cut-off levels of tumor markers in ng/mL.

Abbreviations: PPV, positive predictive value; NPV, negative predictive value; CEA, carcinoembryonic antigen; SCC, squamous cell carcinoma; CYFRA, cytokeratin 19 fragments; NAB, needle aspiration biopsy.

Hur et al.

Hur et al. BMC Cancer 2012 12:392   doi:10.1186/1471-2407-12-392

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