Segmentation differences in developmental stages. Fragmentation patterns which have frequently been observed are shown here; a section of chromosome 5 (55Mb to 85Mb) is taken as an example. Comparing Transgenic1 and Tumor1, one can find not only an increase in copy number alteration, but also a progressive fragmentation of previously found segments. These fragmentation patterns can be found in all WAP-SVT/t derived samples. The results for Normal2, Transgenic2 and Tumor2 were comparable (data not shown).
Standfuß et al. BMC Cancer 2012 12:380 doi:10.1186/1471-2407-12-380