Overview of mouse sample origin. Mammary gland tissue samples from six NMRI mice were analyzed. Two normal samples were derived from two NMRI mice (A) and four mammary gland samples were derived from transgenic WAP-SVT/t mice. The transgenic samples (B) originate from these WAP-SVT/t mice, taken at first day of lactation. After the first lactation period all WAP-SVT/t transgenic mice had developed breast cancer. The two tumor samples were taken from these mice (C). Additionally, two samples from two cell lines were used (D). As described by Klein et al.  these two cell lines were established from mammary gland tumors (E). The Kaplan-Meier survival curve for tumor-free survival after first mating is depicted (F) and the mean latency is marked in blue. A full version of the Kaplan-Meier curve can be found in Figure S1 (Additional file 2). The mouse picture was provided by Seans Potato Business and downloaded from Wikimedia Commons.
Standfuß et al. BMC Cancer 2012 12:380 doi:10.1186/1471-2407-12-380