Tumor regression analysis and virus titers in GLV-1h68 and GLV-1h255 infected tumors. (A) Growth of PC-3 xenograft tumors in athymic nude mice. Animals were i.v. injected with GLV-1h68, GLV-1h255 or PBS. Tumor volumes were measured weekly (n = 6–7). Statistical significance was determined by using a two-tailed Student’s t test (p-values: * < 0.05, ** < 0.01, *** < 0.001). (B) Viral titers (pfu/g tissue) of tumor homogenates 7 days p.i. Titers were obtained by performing a plaque assay on CV-1 cells. Four tumors per group (GLV-1h68, GLV-1h255) were used.
Schäfer et al. BMC Cancer 2012 12:366 doi:10.1186/1471-2407-12-366