Table 6

Multivariate analysis for progression free survival (PFS) in Subgroup A and Subgroup B
PFS
Parameter SE HR 95%CI WAld’s p
Subgroup A(1st line, chemo-naïve)
Age −0.028 0.011 0.973 0.952-0.994 0.012
TYMS
 aberrant vs. normal 0.577 0.253 1.780 1.084-2.923 0.563
Treatment
 platinum vs. taxanes 0.235 0.407 1.265 0.570-2.811 0.563
 tax/plat vs. taxanes −0.220 0.303 0.802 0.443-1.452 0.467
 other vs. taxanes 0.088 0.376 1.092 0.522-2.282 0.816
aberrant TYMS *platinum −1,687 0.564 0.003
aberrant TYMS *tax/plat −1.200 0.433 0.006
Subgroup B(1st line, chemo-naïve)
Age −0.002 0.010 0.978 0.959-0.998 0.034
TYMS
 aberrant vs. normal 0.539 0.255 1.714 1.040-2.824 0.034
Treatment
 platinum vs. taxanes 0.293 0.382 1.340 0.0633-2.836 0.444
 tax/plat vs. taxanes −0.129 0.285 0.879 0.502-1.537 0.650
 other vs. taxanes −6.631 0.439 0.532 0.225-1.258 0.151
aberrant TYMS*platinum −1.719 0.551 0.002
aberrant TYMS*tax/plat −1.233 0.420 0.003
aberrant TYMS *other  treatment −1.375 0.642 0.032

Kotoula et al.

Kotoula et al. BMC Cancer 2012 12:342   doi:10.1186/1471-2407-12-342

Open Data