Table 3

BRCA1, ERCC1, RRM1 and TYMS mRNA expression in the study sample groups
sample category BRCA1 mRNA ERCC1 mRNA RRM1 mRNA TYMS mRNA
reference RNA, RQ
 Mean 36.71 38.22 42.09 39.70
 ±SD 0.28 0.10 0.62 0.48
normal lung tissue (N), RQ 40 40 40 40
 Mean 35.50 38.23 36.86 33.25
 Median 35.66 38.63 37.47 34.10
 ±SD 2.46 2.93 3.02 2.94
 Minimum 22.08 22.08 22.08 25.86
 Maximum 39.54 41.78 41.32 37.37
matched NSCLC tissue (T), RQ 35 35 35 35
 Mean 36.52 38.45 37.99 36.12
 Median 36.98 39.08 38.27 35.57
 ±SD 2.79 2.95 3.13 1.70
 Minimum 23.13 23.13 23.13 32.50
 Maximum 40.34 41.13 41.34 38.77
deltaTN^ 35 35 35 35
 Mean 1.07 0.23 1.13 2.97
 Median 1.00 0.31 1.20 2.38
 ±SD 1.60 1.19 1.37 2.07
 Minimum -1.66 -2.15 -2.24 -0.57
 Maximum 4.55 3.38 3.23 10.17
 95% C.I. 0.52 - 1.62 -0.18 - 0.64 0.66 - 1.60 -0.03 - 3.92
 Sig., 2-tailed (one-sample T-test) 0.0004 0.2610 <0.0001 <0.0001
NSCLC tissue, non-matched, RQ 239 241 241 241
 Mean 36.75 38.87 37.59 36.44
 Median 37.00 39.12 38.52 36.71
 ±SD 1.82 1.74 3.99 2.01
 Minimum 23.40 27.58 19.54 23.85
 Maximum 39.96 41.95 43.02 40.25

Notes to Table 3: ^: relative mRNA expression in matched Tumor (T) vs. Normal (N) tissues followed normal distribution.

Kotoula et al.

Kotoula et al. BMC Cancer 2012 12:342   doi:10.1186/1471-2407-12-342

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