Table 1

Association of B, E, R, T mRNA expression with clinicopathologic parameters of NSCLC
BRCA1 ERCC1 RRM1 TYMS
N median range median range median range median range
All tumors# 36.88 23.13−14.34 39.30 23.13−14.95 38.57 19.54−14.02 36.76 23.85−40.25
Gender
Men 222 37.09 23.13−40.34 39.30 23.13−14.95 38.57 19.54−14.02 36.76 23.85−40.25
Women 54 36.24 32.95−39.22 38.22 35.81−40.87 37.95 30.60−41.94 36.51 30.99−39.88
P 0.0053 0.0169 0.3615 0.4391
Smoking
Never 29 36.16 27.80−39.06 39.01 27.58−40.45 38.19 19.54−41.23 36.45 32.33−39.07
Former 26 36.21 32.13−39.68 38.84 23.13−40.67 38.16 23.13−43.02 36.00 32.63−40.25
Current 150 37.08 32.34−40.34 39.36 32.27−41.95 38.84 23.34−43.02 36.00 32.63−40.25
P 0.0017 0.2694 0.1541 0.0146
Histology
Adeno 159 36.38 23.13−39.24 38.83 23.13−41.95 38.04 20.76−41.60 36.12 30.70−39.36
SCC 70 37.90 33.94−40.34 93.76 35.40−41.23 39.80 19.83−43.02 37.50 23.85−40.20
LCC/undiff 47 37.33 30.15−39.98 39.11 29.58−40.89 38.33 19.54−42.38 37.21 31.59−40.25
P <0.0001 <0.0001 <0.0001 <0.0001
Stage
I & II 53 37.16 23.13−40.34 39.16 23.13−41.13 38.52 22.49−43.02 36.79 23.85−40.20
IIIA 34 37.60 34.74−39.96 39.70 36.22−41.23 39.30 30.60−42.26 37.48 31.89−40.20
IIIB & IV 137 36.61 27.80−39.68 39.26 27.58−41.95 38.54 19.54−42.38 36.57 30.99−40.25
P 0.0064 0.5083 0.2249 0.1006

Notes to Table 1: Medians and range represent RQ values that are expressed as (40-dCT); p = Mann Whitney Asymptotic significance for gender and Kruskal-Wallis for the rest; # = the number of tumors with informative BRCA1 RQ values was 274, and for all other genes 276; undiff = undifferentiated; SCC = squamous cell, and LCC = large cell carcinoma; stage = stage at initial diagnosis.

Kotoula et al.

Kotoula et al. BMC Cancer 2012 12:342   doi:10.1186/1471-2407-12-342

Open Data