BRCA1, ERCC1, RRM1 and TYMS (B, E, R, T) mRNA expression is up-regulated in NSCLC in comparison to non-cancerous lung tissue. A. The distribution of single gene relative quantification (RQ) values is shown for non-cancerous lung tissue (Nm), matched tumor (Tm), and all remaining tumors for which no Nm was available (T). B. Comparison of B, E, R, T mRNA expression in a case-per-case mode. Except for very few cases, these genes, TYMS in particular, are up-regulated in NSCLC in comparison to matched non-cancerous lung tissue. A difference of 3 cycles (Y axis) corresponds to a 10-fold difference in gene expression.
Kotoula et al. BMC Cancer 2012 12:342 doi:10.1186/1471-2407-12-342