Open Access Highly Accessed Research article

Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Vassiliki Kotoula12*, Dimitrios Krikelis3, Vasilios Karavasilis3, Triantafillia Koletsa1, Anastasia G Eleftheraki4, Despina Televantou2, Christos Christodoulou5, Stefanos Dimoudis3, Ippokratis Korantzis3, Dimitrios Pectasides6, Konstantinos N Syrigos7, Paris A Kosmidis8 and George Fountzilas23

Author Affiliations

1 Department of Pathology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

2 Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

3 Department of Medical Oncology, “Papageorgiou” Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

4 Section of Biostatistics, Hellenic Cooperative Oncology Group, Data Office, Athens, Greece

5 Second Department of Medical Oncology, “Metropolitan” Hospital, Piraeus, Greece

6 Oncology Section, Second Department of Internal Medicine, “Hippokration” Hospital, Athens, Greece

7 Oncology Unit GPP, "Sotiria" General Hospital, Athens School of Medicine, Athens, Greece

8 Second Department of Medical Oncology, Hygeia Hospital, Athens, Greece

For all author emails, please log on.

BMC Cancer 2012, 12:342  doi:10.1186/1471-2407-12-342

Published: 6 August 2012

Additional files

Additional file 1:

Table 1:Clinicopathologic characteristics of NSCLC patients and tumors examined.Table 2: Treatment-related patient groups and outcome. Table 3: Selection of the normal RQ value range was based on the highest frequency of RQ values within a 3-cycle range in the normal sample series. Table 4: Initial classification of B, E, R, T RQ values in NSCLC tumors. Figure 1: PFS patterns of patients in Subgroup B (1st line, chemo-naïve + pre-treated) with mRNA RQ values classified in a 3-scale as low, normal and high. Figure 2: Significant but non-specific associations of BRCA1 and RRM1 gene expression with the outcome of 1st line chemo-naïve patients treated with taxanes excluding the platinum doublet. Figure 3: Effect of ERCC1 mRNA expression on the outcome of 1st line chemo-naïve treated patients.

Format: PDF Size: 394KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data