Gene expression profile changes after ectopic expression of ZIC1. (A) The gene expression profiles in pCDNA3.1-ZIC1 or empty pCDNA3.1 vector stable transfectants were analyzed by cDNA microarray in MKN28 cells. Representative genes are illustrated on the right side of the heatmap image using a cut-off >1.5 or < −1.5 fold as a significant difference,. (B) Genes involved in cell cycle, cell proliferation and cell migration according to gene functional analysis (http://www.genecards.org webcite) are presented. Relative fold change is expressed with ratio of pCDNA3.1-ZIC1 versus pCDNA3.1 control. (C) Systemic understanding of pathways for ZIC1 regulation of signaling and target genes in the development and progression of gastric cancer.
Zhong et al. BMC Cancer 2012 12:290 doi:10.1186/1471-2407-12-290