Open Access Research article

Real-imaging cDNA-AFLP transcript profiling of pancreatic cancer patients: Egr-1 as a potential key regulator of muscle cachexia

Alexander Skorokhod14*, Jeannine Bachmann2, Nathalia A Giese3, Marc E Martignoni2 and Holger Krakowski-Roosen1

Author Affiliations

1 Division of Preventive Oncology (G110), National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

2 Department of Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

3 Department of General Surgery, University of Heidelberg, ImNeuenheimer Feld, 110 69120, Heidelberg, Germany

4 Institute of Molecular Biology and Genetics, Ukrainian Academy of Sciences, Zabolotnogo str. 150, 03143, Kiev, Ukraine

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BMC Cancer 2012, 12:265  doi:10.1186/1471-2407-12-265

Published: 21 June 2012

Additional files

Additional file 1:

Figure S1.cDNA-AFLP: Comparison of 10 cachectic and 13 non-cachectic patients using one-primer-pair combination.

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Additional file 2:

Table S1.Candidate biomarkers for cachexia progression. Legend: diff. - differential gene expression: ”+” cachexiaspecific upregulation,“-“cachexia-specific downregulation.

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Additional file 3:

Figure S2.Full-length Western blotting of Egr-1.

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