Table 3

Correlation of tumor subgroups with clinical parameters
Parameter Cluster-1 (n = 35) Cluster-2 (n = 12) Cluster-3 (n = 22) Cluster-4 (n = 14) p-global
Microsatellite instability MSS 33 11 21 9 0.039LR,a
MSI 2 1 1 5
Histologic subtypes Conventional 34 12 21 8 0.001LR,b
Mucinous 1 0 1 6
% Stroma content frozen sample Mean 11.2 18.8 23.4 18.9 <0.001KW,c
SD 6.0 10.3 10.5 14.8
% Stroma Paraffin Mean 12.6 17.1 18.9 16.8 0.047KW,d
SD 6.0 9.9 8.6 14.2
nuclear β-Catenin (IHC) LOW 21 9 11 12 0.021LR,e
MEDIUM 4 0 6 1
HIGH 10 2 5 0
BRAF mutations (V600E) Mutated 0 1 1 6 <0.001LR,f
WT 35 11 21 8
Dukes Stage A 9 5 4 4 0.646LR
B 9 3 6 7
C 8 2 6 2
D 9 2 6 1

LR: Likelihood Ratio. KW: Kruskal Wallis. Pair wise comparisons: a: C4 ≠ C1 (0.015); C4 ≠ C3 (0.024); b: C4 ≠ C1 (0.001); C2 ≠ C4 (0.017); C4 ≠ C3 (0.008); c: C1 ≠ C4 (0.013); C1 ≠ C2 (0.020); C1 ≠ C3 (< 0.001); d: C1 ≠ C3 (0.005); e: C1 ≠ C4 (0.020); C2 ≠ C3 (0.047); C3 ≠ C4 (0.014); f: C4 ≠ C1 (<0.001); C4 ≠ C2 (<0.081); C4 ≠ C3 (0.008); Frozen stroma vs paraffin ICC of 0.781 (IC95% 0.681-0.852) p < 0.001.

Perez Villamil et al.

Perez Villamil et al. BMC Cancer 2012 12:260   doi:10.1186/1471-2407-12-260

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