Table 1

Pathology observed grossly, by anatomical site
Men1+/+;Trp53+/+ Men1+/+;Trp53+/− Men1+/+;Trp53−/− Men1+/−;Trp53+/+ Men1+/−;Trp53+/− Men1+/−;Trp53−/−
Pituitary 4/13 (30.8%) 0/9 0 1/13 (7.7%) 14/19 (73.7%) 11/21 (52.4%) 5/28 (17.9%)
Pancreas 0/13 0 1/9 (11.1%) 1/13 (7.7%) 13/19 (68.4%) 12/22 (54.5%) 4/28 (14.3%)
Thyroid 3/11 (27.3%) 0/8 0 0/11 0 5/17 (29.4%) 9/22 (40.9%) 4/27 (14.8%)
Parathyroid 1/11 (9.1%) 1/8 (12.5%) 0/11 0 4/17 (23.5%) 5/22 (22.7%) 0/27 0
Thymus 0/13 0 0/9 0 3/13 (23.1%) 1/19 (5.9%) 2/22 (9.1%) 11/28 (39.3%)
Lymph Nodes 2/13 (15.3%) 3/9 (33.3%) 9/13 (69.2%) 4/19 (21.1%) 9/22 (40.1%) 20/28 (71.4%)
Spleen 1/13 (7.7%) 1/9 (11.1%) 7/13 (53.8%) 3/19 (15.8%) 4/22 (18.2%) 21/28 (75.0%)
Muscle 0/13 0 1/9 (11.1%) 5/13 (38.5%) 1/19 (5.3%) 3/22 (13.6%) 6/28 (21.4%)
Bone 0/13 0 3/9 (33.3%) 0/13 0 3/19 (15.8%) 2/22 (9.1%) 1/28 (3.6%)
Bladder/Urethra 0/13 0 2/9 (22.2%) 0/13 0 0/19 0 0/22 0 1/27 (3.7%)
Prostate/Seminal Vesicles 2/5 (40.0%) 2/6 (33.3%) 1/5 (20.0%) 1/9 (11.1%) 4/12 (33.3%) 1/15 (6.7%)
Testes 0/5 0 1/6 (16.7%) 1/5 (20.0%) 5/9 (55.6%) 7/12 (58.3%) 2/16 (12.5%)
Uterus 3/8 (37.5%) 2/3 (66.7%) 0/8 0 2/10 (20.0%) 0/10 0 0/11 0
Ovaries 0/8 0 1/3 (33.3%) 1/8 (12.5%) 5/10 (50.0%) 6/10 (60.0%) 5/11 (45.5%)
Mammary Glands 1P/13 (7.7%) 0/9 0 0/6 0 1 L/18 (5.6%) 1 L,1P/17 (5.9%L,5.9%P) 0/14 0
Adrenal Glands 0/13 0 1/8 (12.5%) 3/13 (23.1%) 5/18 (27.8%) 9/21 (42.6%) 6/28 (21.4%)
Lung 3/13 (23.1%) 1/9 (11.1%) 3/13 (23.1%) 2/19 (10.5%) 4/21 (19.0%) 3/28 (10.7%)
Liver 1/13 (7.7%) 3/9 (33.3%) 3/13 (23.1%) 1/19 (5.3%) 2/21 (9.5%) 6/28 (21.4%)

Data are shown as "Number of animals with abnormal or pathology observation"/"Total number of animals" (percentage of cohort), tabulated by genotype group. For mammary observations, L indicates appearance similar to lactation as seen during normal pregnancy or suckling, as we have previously observed in some animals with pituitary prolactinoma, P indicates other pathology.

Loffler et al.

Loffler et al. BMC Cancer 2012 12:252   doi:10.1186/1471-2407-12-252

Open Data