Color change of xenografts 32 h after the treatment with taxol [B], 8 h after the treatment with ASA404 [C] or 32 h after the treatment with taxol plus a ASA404 during the last 8 h [D]. Xenograft [A] represents an untreated control. Treatment with ASA404 as a sole agent or in combination with taxol most probably caused change of permeability and selective disruption of blood vessels within tumors followed by hemorrhagic necrosis.
Milanović et al. BMC Cancer 2012 12:242 doi:10.1186/1471-2407-12-242